Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia.
J Am Chem Soc
; 132(45): 15846-8, 2010 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-20979363
ABSTRACT
Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Azo
/
Espectroscopia de Luz Próxima ao Infravermelho
/
Transferência Ressonante de Energia de Fluorescência
/
Corantes Fluorescentes
/
Isquemia
/
Hipóxia
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article