Neuromuscular pathology in mice lacking alpha-synuclein.
Neurosci Lett
; 487(3): 350-3, 2011 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-21029764
ABSTRACT
This work was undertaken in order to study the possible role of alpha-synuclein in the function of the neuro-muscular junction in skeletal muscles. Repeated stimulation of skeletal muscle motor neurons revealed signs of neuromuscular pathology in alpha-synuclein null mutated (C57Bl/6JOlaHsd) and knockout (B6;129X1-Snca(tm1Rosl)/J) mice. This stimulation produced repetitive compound muscle action potentials in both lines of alpha-synuclein deficient mice. Muscle strength and muscle coordination during ambulation were unaffected, though motor learning was slower in alpha-synuclein deficient mice in the Rotarod test. We conclude that alpha-synuclein may play a role in acetylcholine compartmentalization at the neuromuscular junction, and in the fine control of activity of skeletal muscles.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Doenças da Junção Neuromuscular
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Alfa-Sinucleína
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Atividade Motora
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article