Inhibitory effect of panduratin A isolated from Kaempferia panduarata Roxb. on melanin biosynthesis.
Phytother Res
; 24(11): 1600-4, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-21031615
ABSTRACT
Hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, thus melanin synthesis inhibitors have been of great interest as target molecules for cosmetic and medicinal purposes. The aim of this study was to investigate the in vitro inhibitory effect of panduratin A, isolated from Kaempferia pandurata Roxb., on melanogenesis and its related enzymes such as tyrosinase, tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) in melan-a murine melanocytes. The IC(50) values of panduratin A for melanogenesis and tyrosinase were 9.6 µm and 8.2 µm, respectively, while those of arbutin as a positive control were 990 µm and 660 µm, respectively. In western blot analysis, panduratin A also significantly decreased tyrosinase, TRP-1 and TRP-2 protein levels. These results indicate that panduratin A effectively inhibits melanin biosynthesis, thus creating the possibility of developing a new skin-whitening agent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zingiberaceae
/
Chalconas
/
Melaninas
/
Melanócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article