Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists.
Bioorg Med Chem Lett
; 20(24): 7483-7, 2010 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-21041081
ABSTRACT
The design, synthesis and calcimimetic properties of various cyclic sulfonamides and sulfamates are described. The latter were prepared from the corresponding o-alkenylarenesulfonamides via copper- or rhodium-catalyzed intramolecular aziridination. The size of the cyclic sulfonamide rings as well as the position of the crucial (R)-naphthylethylamine substituent significantly affected calcimimetic activity. The most active compounds were the six- and seven-membered sulfonamides 30a and 31a and sulfamate 34a.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Ácidos Sulfônicos
/
Receptores de Detecção de Cálcio
/
Calcimiméticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article