[Evaluation of the myocardial systolic function and ventricular remodeling of rats with experimental myocardial infarction by strain/strain rate imaging and MMP-9].
Zhonghua Xin Xue Guan Bing Za Zhi
; 38(7): 597-600, 2010 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-21055280
ABSTRACT
OBJECTIVE:
To evaluate the myocardial systolic function and ventricular remodeling in heart failure rat induced by myocardial infarction (MI) with S/SRI and MMP-9.METHODS:
A total of 70 male SD rats were randomly assigned to 4 groups 4 weeks and 8 weeks MI (anterior descending branch of left coronary artery were ligated), sham operation (thoracotomy without ligation of coronary artery) and non-operated control group. The regional myocardial systolic function of rats was quantified with S/SRI. The myocardial MMP-9 expression was detected by Western blot.RESULTS:
In the 4 weeks MI group, all segment's Ssys, SRsys, the strain of end-systole were reduced while PSI was increased compared to sham and non-operated group with the exception of the inferior wall. These changes were more significant in 8 weeks MI group compared to the 4 weeks MI group. In the 4 weeks MI group, the expression of MMP-9 was significantly upregulated than the sham operation group and this upregulation was more significant at 8 weeks post MI.CONCLUSIONS:
S/SRI can quantitative evaluate the regional systolic function of heart failure rat induced by myocardial infarction. Progressive upregulation of myocardial MMP-9 expression paralleled the deterioration of regional systolic function in this heart failure rat model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Remodelação Ventricular
/
Metaloproteinase 9 da Matriz
/
Insuficiência Cardíaca
/
Contração Miocárdica
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article