[Inhibitory effect of total glucosides of paeonia on the NF-κB/p65 protein expression in paws of RA rats].

ABSTRACT

AIM: To explore effects of total glucosides of paeonia (TGP)on the NF-κB/p65 protein expression in paws of rheumatoid arthritis (RA) rats, and the contents of serum TNF-α, IL-1ß and IL-10 in RA rats serum. METHODS: Type II collagen-induced arthritis model in SD rats was established. The expression of NF-κB/p65 proteins in rat, s paw tissues was detected by immunohistochemical staining. The contents of serum TNF-α, IL-1ß and IL-10 in RA rats were detected by ELISA. RESULTS: TGP could down-regulate the expression of NF-κB/ p65 protein and contents of TNF-α, IL-1ß and IL-10 in RA rats. CONCLUSION: The inhibitory effect of TGP on anti-inflammation maybe related to decreasing the expression of NF-κB/p65 protein and suppressing the production of TNF-α and IL-1ß in RA rats.