[Melanin and its role on the virulence of Cryptococcus neoformans]. / Melanin ve Cryptococcus neoformans'in virülansi üzerindeki rolü
Mikrobiyol Bul
; 44(3): 519-26, 2010 Jul.
Article
em Tr
| MEDLINE
| ID: mdl-21064003
ABSTRACT
Melanins can be produced by some species of pathogenic bacteria, helminths and fungi. The production of melanin appears to contribute to microbial pathogenesis owing to its potential for protection against host defence systems. Melanin synthesis in Cryptococcus neoformans has been associated with virulence by the ability to protect against phagocytosis, oxidative injury and phagocytic killing. Moreover, it was shown that, melanization of C.neoformans has involved in protection against some antifungal compounds. The detection of the association between melanin and microbial virulence might provide new treatment and prevention strategies targeting the inhibition of melanin polymerization. In this review article, the impact of melanin on virulence of C.neoformans has been discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Criptococose
/
Cryptococcus neoformans
/
Melaninas
Limite:
Animals
/
Humans
Idioma:
Tr
Ano de publicação:
2010
Tipo de documento:
Article