Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization.
J Immunol
; 185(12): 7156-60, 2010 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-21068400
ABSTRACT
Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Timo
/
Linfócitos T
/
Receptores de Antígenos de Linfócitos T gama-delta
/
Modelos Imunológicos
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article