Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.
Gastroenterology
; 140(2): 435-41, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21070776
ABSTRACT
BACKGROUND & AIMS:
An association between gastric cancer and the rs2294008 (C>T) polymorphism in the prostate stem cell antigen (PSCA) gene has been reported for several Asian populations. We set out to determine whether such an association exists in white individuals.METHODS:
We genotyped 166 relatives of gastric cancer patients, including 43 Helicobacter pylori-infected subjects with hypochlorhydria and gastric atrophy, 65 infected subjects without these abnormalities, 58 H pylori-negative relatives, and 100 population controls. Additionally, a population-based study of chronic atrophic gastritis provided 533 cases and 1054 controls. We then genotyped 2 population-based, case-control studies of upper gastrointestinal cancer the first included 312 gastric cancer cases and 383 controls; the second included 309 gastric cancer cases, 159 esophageal cancer cases, and 211 controls. Odds ratios were computed from logistic models and adjusted for confounding variables.RESULTS:
Carriage of the risk allele (T) of rs2294008 in PSCA was associated with chronic atrophic gastritis (adjusted odds ratio [OR], 1.5; 95% confidence interval [CI] 1.1-1.9) and noncardia gastric cancer (OR, 1.9; 95% CI 1.3-2.8). The association was strongest for the diffuse histologic type (OR, 3.2; 95% CI 1.2-10.7). An inverse association was observed between carriage of the risk allele and gastric cardia cancer (OR, 0.5; 95% CI 0.3-0.9), esophageal adenocarcinoma (OR, 0.5; 95% CI 0.3-0.9), and esophageal squamous cell carcinoma (OR, 0.4; 95% CI 0.2-0.9).CONCLUSIONS:
The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Polimorfismo de Nucleotídeo Único
/
Neoplasias Gastrointestinais
/
Antígenos de Neoplasias
/
Proteínas de Neoplasias
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article