Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Bioorg Med Chem Lett
; 21(1): 463-6, 2011 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-21074994
ABSTRACT
The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines, incorporating 2,3,4,5-tetrahydro-benzo[d]azepine fragments, is described. An orally bioavailable analogue (18) that displayed antitumor efficacy in ALCL xenograft models in mice was identified and extensively profiled.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Benzazepinas
/
Proteínas Tirosina Quinases
/
Linfoma Anaplásico de Células Grandes
/
Inibidores de Proteínas Quinases
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article