p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
Proc Natl Acad Sci U S A
; 107(49): 20947-51, 2010 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-21078964
ABSTRACT
Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death. The tumor suppressor p53 responds to genotoxic stress by engaging a transcriptional program leading to cell-cycle arrest or apoptosis. We demonstrate that IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Supressora de Tumor p53
/
Apoptose
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Fosfotransferases (Aceptor do Grupo Fosfato)
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Neoplasias do Colo
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article