Effects of Hypericum Perforatum, in a rodent model of periodontitis.
BMC Complement Altern Med
; 10: 73, 2010 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-21092263
ABSTRACT
BACKGROUND:
Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of Hypericum perforatum in animal model of periodontitis.METHODS:
Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.RESULTS:
Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.CONCLUSIONS:
Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodontite
/
Extratos Vegetais
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Hypericum
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Infiltração de Neutrófilos
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Fitoterapia
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Anti-Inflamatórios
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Mucosa Bucal
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article