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ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.
Kim, Sang Gyun; Choo, Andrew Y; Blenis, John.
Afiliação
  • Kim SG; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Mol Cell ; 40(4): 501-2, 2010 Nov 24.
Article em En | MEDLINE | ID: mdl-21095578
ABSTRACT
Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2010 Tipo de documento: Article