Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.
Bioorg Med Chem Lett
; 20(24): 7454-7, 2010 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-21106455
ABSTRACT
Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Inibidores de Proteínas Quinases
/
Janus Quinase 1
/
Janus Quinase 2
/
Janus Quinase 3
/
TYK2 Quinase
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article