Regulation of microRNA-145 by growth arrest and differentiation.
Exp Cell Res
; 317(4): 488-95, 2011 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-21111732
ABSTRACT
MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Regulação para Cima
/
MicroRNAs
/
Inibidores do Crescimento
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article