Highly effective generic adjuvant systems for orphan or poverty-related vaccines.
Vaccine
; 29(5): 873-7, 2011 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-21115053
ABSTRACT
Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Vacinas contra Antraz
/
Lipossomos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article