Aneuploidy as an early mechanistic event in metal carcinogenesis.
Biochem Soc Trans
; 38(6): 1650-4, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21118142
ABSTRACT
Aneuploidy has recently been proposed as an initiating event for carcinogenesis. There is significant evidence that carcinogenic metals induce aneuploidy. Here we review the mechanisms for how carcinogenic metals may induce aneuploidy and the evidence that carcinogenic metals induce an aneugenic effect which can destabilize the genome leading to genomic instability and cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Aneuploidia
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Metais
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article