A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging.
J Nanosci Nanotechnol
; 10(12): 8118-23, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-21121304
ABSTRACT
Molecular imaging techniques now allow recognition of early biochemical, physiological, and anatomical changes before manifestation of gross pathological changes. Photoacoustic imaging represents a novel non-ionizing detection technique that combines the advantages of optical and ultrasound imaging. Noninvasive photoacoustic tomography (PAT) imaging in combination with nanoparticle-based contrast agents show promise in improved detection and diagnosis of cardiovascular and cancer related diseases. In this report, a novel strategy is introduced to achieve self-assembled colloidal gold nanorods, which are constrained to the vasculature. Gold nanorods (2-4 nm) were incorporated into the core of self-assembled lipid-encapsulated nanoparticles (sGNR) (approximately 130 nm), providing more than hundreds of gold atoms per nanoparticle of 20% colloid suspension. The physico-chemical characterization in solution and anhydrous state with analytical techniques demonstrated that the particles were spherical and highly mono dispersed. In addition to the synthesis and characterization, sensitive near-infrared photoacoustic detection was impressively demonstrated in vitro.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomografia
/
Meios de Contraste
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Espectroscopia de Luz Próxima ao Infravermelho
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Nanotubos
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Nanopartículas Metálicas
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Ouro
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article