The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice.
Neurosci Lett
; 489(2): 131-5, 2011 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-21145938
ABSTRACT
In the present study, we investigated the antidepressive activity of opiorphin with central administration in the forced swim test in mice. Intracerebroventricular (i.c.v.) administration of opiorphin (1-6 µg/mouse) dose-dependently decreased the immobility time, which was reversed by nonselective opioid receptor antagonist naloxone, δ-selective naltrindole and µ-selective ß-FNA. The data suggested that central administration of opiorphin produced an antidepressant-like effect by activating both µ and δ opioid receptors indirectly. In order to eliminate the possibility of a false-positive result in the forced swim test, locomotor activity was checked in both non-habituated and habituated mice. Opiorphin had no influence on non-habituated mice, though had weak effect on habituated mice. In addition, mice treated with opiorphin did not display any convulsive behaviors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
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Proteínas e Peptídeos Salivares
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Receptores Opioides delta
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Receptores Opioides mu
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Atividade Motora
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Antidepressivos
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article