Efficacy of low-dose caudal clonidine in reduction of sevoflurane-induced agitation in children undergoing urogenital and lower limb surgery: a prospective randomised double-blind study.
Eur J Anaesthesiol
; 28(5): 329-33, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21150631
ABSTRACT
BACKGROUND:
Sevoflurane is commonly used as an inhalational induction agent in paediatric patients. Emergence agitation is a common post-operative problem in young children who have received sevoflurane. Clonidine has proven to be effective in reducing the incidence of post-operative agitation at a higher dose (3 and 2 µg kg⻹). It has some dose-dependent disadvantages, prominently bradycardia, hypotension and respiratory impairment.OBJECTIVE:
The authors conducted a study to evaluate the effectiveness of low-dose caudal clonidine (1 µg kg⻹) in reducing the incidence of sevoflurane-induced agitation in preschool children undergoing urogenital and lower limb surgery.METHODOLOGY:
A double-blind study was conducted comparing 0.25% (0.75 ml kg⻹) bupivacaine and clonidine 1 µg kg⻹ (group 1), 0.25% bupivacaine (0.75 ml kg⻹) and clonidine 0.75 µg kg⻹ (group 2), with 0.25% bupivacaine (0.75 ml kg⻹) alone (group 3). Ninety children of 1-5 years of American Society of Anesthesiologists I and II were randomly assigned into three groups. Post-operatively, patients were monitored for 1 h to observe emergence agitation, which was assessed with the help of Pain and Discomfort Scale.RESULT:
Post-anaesthetic agitation was observed in two patients (6.6%) in group 1, eight patients (26.6%) in group 2 as compared to 12 patients (40%) in group 3 after 15 min of post-operative observation. The mean scores in group 1 at 15 and 30 min were significantly lower than those in group 3 (P value <0.05). None of the groups had showed any haemodynamic and respiratory compromise, either clinically and statistically.CONCLUSION:
Caudal clonidine at a lower dose (1 µg kg⻹) could be effective in reducing the incidence of sevoflurane-induced emergence agitation in children undergoing urogenital and lower limb surgery without any significant adverse effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agitação Psicomotora
/
Bupivacaína
/
Clonidina
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Éteres Metílicos
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article