[Effects of melatonin on anti-oxidative function of lung injury induced by lipopolysaccharide in rats and ICAM-1 expression].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 24(4): 464-7, 2008 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-21158154
ABSTRACT
AIM:
To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism.METHODS:
All rats were randomly divided into four groups control group, lipopolysaccharide (LPS) group, dexamethasone (DEX) and MT treatment group. Myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity and malonaldehyde (MDA) content of lung tissues were detected at 3, 6 and 12 h after intratracheal instillation in each group. In addition, the expression of intercellular adhesion molecule-1 (ICAM-1) were observed through immunohistochemistry staining in lung tissues.RESULTS:
Compared with control group, SOD activity decreased significantly in LPS group (P < 0.01), but MPO activity,MDA content and the expression of ICAM-1 increased obviously (P < 0.01). The administration of MT and DEX mitigated above changes significantly (P < 0.05 or P < 0.01).CONCLUSION:
MT possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the expression of ICAM-1 probably.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Molécula 1 de Adesão Intercelular
/
Lesão Pulmonar Aguda
/
Melatonina
/
Antioxidantes
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article