Cytotoxic amide alkaloids from Piper boehmeriaefolium.
J Nat Prod
; 74(1): 45-9, 2011 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-21158422
ABSTRACT
Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 µg/mL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Medicamentos de Ervas Chinesas
/
Piper
/
Alcaloides
/
Amidas
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article