[Effect of electroacupuncture on pain threshold and spinal NR2B subunit expression in a rat model of neuropathic pain].
Nan Fang Yi Ke Da Xue Xue Bao
; 30(12): 2702-4, 2010 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-21177185
ABSTRACT
OBJECTIVE:
To observe the effect of electroacupuncture (EA) on pain threshold and spinal NR2B subunit expression in a rat model of neuropathic pain due to chronic compression injury (CCI) of the sciatic nerve and explore the analgesic mechanism of EA.METHODS:
Male SD rats weighing 200-280 g were randomly divided into 4 groups (n=10), namely the sham-operated group, CCI group, EA+CCI group, and sham EA+CCI group. All the rats underwent tests of the mechanical withdrawal threshold and thermal threshold. On day 13 after the surgery, all the rats were decapitated to collect the L4-6 segments of the spinal cord to examine NR2B expression using Western blotting.RESULTS:
The postoperative mechanical withdrawal threshold and thermal threshold were significantly lowered in CCI, EA+CCI and sham EA+CCI groups as compared to those before the surgery (P<0.05). EA obviously alleviated the hypersensitivity in the rats with CCI and inhibited spinal NR2B expressions (P<0.05). No significant differences were found in the mechanical withdrawal threshold, thermal threshold or spinal NR2B subunit expression between CCI group and sham EA+CCI group (P>0.05).CONCLUSION:
EA may alleviate neuropathic hypersensitivity partially by inhibiting NR2B expression in the spinal cord of rats with neuropathic pain resulting from CCI of the sciatic nerve.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletroacupuntura
/
Receptores de N-Metil-D-Aspartato
/
Neuralgia
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article