[The level of fluoxetine in blood plasma and washed from eritrizite supernatant].
Georgian Med News
; (188): 80-3, 2010 Nov.
Article
em Ru
| MEDLINE
| ID: mdl-21178209
ABSTRACT
Antidepressant Fluoxetine and their major therapeutically active metabolite Norfluoxetine was monitored in albumene and glicoproteene of blood plasma and washed from eritrozite supernatant. In paper we describe rapid and reliable method using high-performance liquid chromatography for simultaneous measurement of plasma and supernatant concentration of Fluoxetine and Norfluoxetine. The described method has been successfully used in clinical and laboratory cases. Large interindividual variations in plasma and supernatan concentrations of Fluoxetine and their major metabolite have been shown. In albumene fractions of blood plasma the level of Fluoxetine is more higher then in supernatant. A successful development of the clinico-pharmacokinetic direction at the present stage is due to improvement and standardization of methods of clinical and pharmacokinetic examination which help to ensure a reliable pretreatment identification of patients potentially sensitive to pharmacotherapy with antidepressants.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluoxetina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Antidepressivos de Segunda Geração
Limite:
Animals
Idioma:
Ru
Ano de publicação:
2010
Tipo de documento:
Article