[The roles of carbon monoxide on hypoxic pulmonary vasoconstriction].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 18(3): 261-3, 2002 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-21180065
ABSTRACT
AIM AND METHODS:
To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).RESULTS:
Hypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.CONCLUSION:
ZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Pulmonar
/
Vasoconstrição
/
Monóxido de Carbono
/
Hipóxia
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2002
Tipo de documento:
Article