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Decreased glucose tolerance and plasma adiponectin:resistin ratio in a mouse model of post-traumatic stress disorder.
Castañeda, T R; Nogueiras, R; Müller, T D; Krishna, R; Grant, E; Jones, A; Ottaway, N; Ananthakrishnan, G; Pfluger, P T; Chaudhary, N; Solomon, M B; Woods, S C; Herman, J P; Tschöp, M H.
Afiliação
  • Castañeda TR; Department of Medicinal and Biological Chemistry, College of Pharmacy and Center for Diabetes and Endocrine Research, College of Medicine, University of Toledo, Toledo, OH, USA.
Diabetologia ; 54(4): 900-9, 2011 Apr.
Article em En | MEDLINE | ID: mdl-21181395
ABSTRACT
AIMS/

HYPOTHESIS:

Obesity and type 2 diabetes are among the most serious health pathologies worldwide. Stress has been proposed as a factor contributing to the development of these health risk factors; however, the underlying mechanisms that link stress to obesity and diabetes need to be further clarified. Here, we study in mice how chronic stress affects dietary consumption and how that relationship contributes to obesity and diabetes.

METHODS:

C57BL/6J mice were subjected to chronic variable stress (CVS) for 15 days and subsequently fed with a standard chow or high-fat diet. Food intake, body weight, respiratory quotient, energy expenditure and spontaneous physical activity were measured with a customised calorimetric system and body composition was measured with nuclear magnetic resonance. A glucose tolerance test was also applied and blood glucose levels were measured with a glucometer. Plasma levels of adiponectin and resistin were measured using Lincoplex kits.

RESULTS:

Mice under CVS and fed with a high-fat diet showed impaired glucose tolerance associated with low plasma adiponectinresistin ratios. CONCLUSIONS/

INTERPRETATION:

This study demonstrates, in a novel mouse model, how post-traumatic stress disorder enhances vulnerability for impaired glucose metabolism in an energy-rich environment and proposes a potential adipokine-based mechanism.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article