Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.
FEBS Lett
; 585(2): 440-6, 2011 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-21192933
ABSTRACT
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queratinócitos
/
Diferenciação Celular
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Calgranulina A
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Calgranulina B
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Proliferação de Células
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article