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Towards molecular imaging of multiple sclerosis.
Owen, David R J; Piccini, Paola; Matthews, Paul M.
Afiliação
  • Owen DR; Division of Experimental Medicine, Imperial College, Hammersmith Hospital, London, UK.
Mult Scler ; 17(3): 262-72, 2011 Mar.
Article em En | MEDLINE | ID: mdl-21212087
Magnetic resonance imaging (MRI) has had a profound impact on both research and clinical management of multiple sclerosis (MS), but signal changes reflect underlying neuropathology only indirectly and often non-specifically. Positron emission tomography (PET) offers the potential to complement MRI with quantitative measures of molecularly specific markers of cellular and metabolic processes. PET radiotracers already available promise new insights into the dynamics of the innate immune response, neuronal function, neurodegeneration and remyelination. Because PET is an exquisitely sensitive technique (able to image even picomolar concentrations), only microdoses of radioligand (<10 µg) are needed for imaging. This facilitates rapid implementation of novel radioligands because extensive toxicology data is not required. In the future, molecular imaging could assist clinical decision-making with patient stratification for optimization of treatment selection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Imagem Molecular / Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Imagem Molecular / Esclerose Múltipla Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article