Serum galectin-3 levels in patients with Behçet's disease: association with disease activity over a long-term follow-up.
J Eur Acad Dermatol Venereol
; 25(10): 1168-73, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21214630
ABSTRACT
BACKGROUND:
There is a need for a laboratory marker that correlates with the clinical activity of Behçet's disease (BD).OBJECTIVE:
We aimed to investigate whether serum galectin-3 (Gal-3) levels were affected during the course of the disease with regard to disease activity.METHODS:
A total of 131 subjects were involved in the study as follows Group 1 BD active (n = 39); Group 2 BD inactive (n = 31); Group 3 Disease controls with leucocytoclastic vasculitis confirmed with a skin biopsy (n = 22); and Group 4 Healthy control subjects (n = 39). The BD patients were followed regularly and samples were taken in their active and inactive periods of the disease over a 2-year period.RESULTS:
Serum Gal-3 levels were significantly higher in active BD patients (mean 2.38) than inactive BD patients (mean 0.63; P < 0.0001) and the healthy control subjects (mean 0.75; P < 0.0001). There was no significant difference between the leucocytoclastic vasculitis and active BD patients (P = 0.093). Serum Gal-3 levels were positively correlated with clinical activity scores of active BD patients (r = 0.66, P < 0.0001). In addition, the Gal-3 levels were significantly higher in the active disease period when compared with the inactive period during the follow-up. There were no significant differences between the two inactive periods of the disease among the same patients. Further analyses revealed that patients with vascular involvement had significantly higher Gal-3 levels than the other active BD patients (mean 7.57; P = 0.007).LIMITATIONS:
The limitation of the study is the small number of patients with vascular involvement in the active BD patient group.CONCLUSION:
Gal-3 levels are correlated with the activity of Behçet's disease especially with the vascular involvement.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Behçet
/
Progressão da Doença
/
Galectina 3
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article