Anti-prion activity of protein-bound polysaccharide K in prion-infected cells and animals.
Biochem Biophys Res Commun
; 405(2): 285-90, 2011 Feb 11.
Article
em En
| MEDLINE
| ID: mdl-21219866
ABSTRACT
Protein-bound polysaccharide K (PSK) is a clinical immunotherapeutic agent that exhibits various biological activities, including anti-tumor and anti-microbial effects. In the present study, we report on the anti-prion activity of PSK. It inhibited the formation of protease-resistant abnormal prion protein in prion-infected cells without any apparent alterations in either the normal prion protein turnover or the autophagic function in the cells. Its anti-prion activity was predominantly composed of the high molecular weight component(s) of the protein portion of PSK. A single subcutaneous dose of PSK slightly but significantly prolonged the survival time of peritoneally prion-infected mice, but PSK-treated mice produced neutralizing antibodies against the anti-prion activity of PSK. These findings suggest that PSK is a new anti-prion substance that may be useful in elucidating the mechanism of prion replication, although the structure of the anti-prion component(s) of PSK requires further evaluation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Proteínas Fúngicas
/
Doenças Priônicas
/
Proteínas PrPC
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article