Sarcoidosis complicating treatment with natalizumab for Crohn's disease.
Thorax
; 66(12): 1109-10, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21233484
ABSTRACT
Natalizumab is a humanised monoclonal antibody targeting the lymphocyte adhesion molecule a4 integrin, with proven efficacy in multiple sclerosis (MS) and Crohn's disease (CD). The development of sarcoidosis with extrapulmonary involvement is reported in two patients with refractory CD who had received maintenance therapy with natalizumab. This complication has not been previously reported. It is hypothesised that the effect of natalizumab in altering lymphocyte mucosal trafficking may underlie the development of sarcoidosis in these patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
/
Sarcoidose Pulmonar
/
Anticorpos Monoclonais Humanizados
/
Anticorpos Monoclonais
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article