Synthesis of novel angular spirocyclic azetidines.
Org Lett
; 13(4): 780-3, 2011 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-21235246
ABSTRACT
The syntheses of a variety of novel angular azaspiro[3.3]heptanes are reported. gem-Difluoro and gem-dimethyl variants of the angular 1,6-diazaspiro[3.3]heptane module were prepared in high yields using efficient sequences. Additionally, a practical one-pot synthesis of 5-oxo-2-azaspiro[3.3]heptanes and subsequent conversions into functionalized derivatives are described. The methods reported are amenable to the synthesis of these building blocks for drug discovery as members of a library or individually on a preparative scale.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Azetidinas
/
Heptanos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article