High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.
PLoS One
; 6(1): e16148, 2011 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-21249135
ABSTRACT
The HIV-1 protein, Tat has been implicated in AIDS pathogenesis however, the amount of circulating Tat is believed to be very low and its quantification has been difficult. We performed the quantification of Tat released from infected cells and taken up by neurons using high performance capillary electrophoresis. This is the first report to successfully measure the amount of Tat in neurons and places Tat as a key player involved in HIV-associated neurocognitive disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos do Gene tat
/
HIV-1
/
Eletroforese Capilar
/
Neurônios
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article