[Tiotropium bromide for treating chronic obstructive pulmonary disease].
Eksp Klin Farmakol
; 73(11): 15-8, 2010 Nov.
Article
em Ru
| MEDLINE
| ID: mdl-21254592
ABSTRACT
Five different types of muscarine-sensitive receptors were identified until now. In routine practice, the nonselective antagonist of cholinoreceptors are replaced by ipratropium bromide that is selectively blocking M1, M2, and M3 subtypes with the same affinity to each of them. However, the blockage of M2 subtype leads to bronchoconstriction and is accompanied by inhibition of M3 receptors in bronchial smooth muscles. The new drug tiotropium bromide selectively inhibits only the M1 and M3 types of receptors and does not affect the M2 subtype. This drug is administered only once a day, which is very important in clinical practice. Thus tiotropium bromide is the drug of choice for basic therapy of COPD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Derivados da Escopolamina
/
Broncodilatadores
/
Doença Pulmonar Obstrutiva Crônica
Limite:
Animals
/
Humans
Idioma:
Ru
Ano de publicação:
2010
Tipo de documento:
Article