Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture.
Neurosci Lett
; 118(2): 235-7, 1990 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-2125713
ABSTRACT
Muscarinic receptors are involved in CNS neurotransmissions and have been shown to transduce their message by modulating cAMP, calcium, inositol phosphates, and more recently, by liberating arachidonic acid via phospholipase A1. We have previously shown that the alpha 1-adrenergic and 5-HT2 serotonergic neurotransmitter receptors cause the release of arachidonic acid from spinal cord and hippocampal neurons, respectively, in primary culture. In this study, we demonstrated a muscarinic receptor-mediated release of arachidonic acid in these two neural segments which occurred independent of phosphatidylinositol-specific phospholipase C. This release of arachidonic acid was neuronal (not glial) in origin and exhibited M1 muscarinic receptor pharmacology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Ácidos Araquidônicos
/
Receptores Muscarínicos
/
Hipocampo
/
Neurônios
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article