A convenient synthesis of the side chain of loteprednol etabonate--an ocular soft corticosteroid from 20-oxopregnanes using metal-mediated halogenation as a key reaction.
Steroids
; 76(5): 497-501, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21277882
ABSTRACT
A facile synthesis of the side chain of loteprednol etabonate, namely, chloromethyl-17α-[(ethoxycarbonyl))oxy]-11ß-hydro of loteprednol etabonate, viz., chloromethyl-17α-[(ethoxycarbonyl))oxy]-11xy-3-oxoandrosta-1,4-diene-17ß-carboxylate--an ocular soft corticosteroid, has been described starting from a 20-oxopregnane, namely, 3ß-acetoxy-pregn-5(6),16(17)-diene-20-one (16-dehydropregnenolone acetate, i.e., 16-DPA) using our recently developed metal-mediated halogenation as a key reaction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnanos
/
Androstadienos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article