ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor.
J Gen Virol
; 92(Pt 5): 1228-1232, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21289159
ABSTRACT
The adenosine deaminases acting on RNA (ADAR) enzymes catalyse conversion of adenosine to inosine in dsRNA. A positive effect of ADAR1 on human immunodeficiency virus type 1 (HIV-1) replication has recently been reported. Here, we show that another ADAR enzyme, ADAR2, positively affects the replication process of HIV-1. We found that, analogously to ADAR1, ADAR2 enhances the release of progeny virions by an editing-dependent mechanism. However, differently from the ADAR1 enzyme, ADAR2 does not increase the infectious potential of the virus. Importantly, downregulation of ADAR2 in Jurkat cells significantly impairs viral replication. Therefore, ADAR2 shares some but not all proviral functions of ADAR1. These results suggest a novel role of ADAR2 as a viral regulator.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
Adenosina Desaminase
/
HIV-1
/
Provírus
/
Interações Hospedeiro-Patógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article