Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses.
J Virol
; 85(9): 4596-601, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21325408
ABSTRACT
Here, we assessed the effects of PB1-F2 and NS1 mutations known to increase the pathogenicity of influenza viruses on the replication and pathogenicity in mice of pandemic (H1N1) 2009 influenza viruses. We also characterized viruses possessing a PB1-F2 mutation that was recently identified in pandemic (H1N1) 2009 influenza virus isolates, with and without simultaneous mutations in PB2 and NS1. Our results suggest that some NS1 mutations and the newly identified PB1-F2 mutation have the potential to increase the replication and/or pathogenicity of pandemic (H1N1) 2009 influenza viruses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Replicação Viral
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Proteínas não Estruturais Virais
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Substituição de Aminoácidos
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Vírus da Influenza A Subtipo H1N1
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article