Validation of VASO cerebral blood volume measurement with positron emission tomography.
Magn Reson Med
; 65(3): 744-9, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21337407
ABSTRACT
Cerebral blood volume (CBV) has been shown to be an important biomarker in a number of neurological disorders and in the quantitative interpretation of functional MRI. One approach to determine CBV in humans is vascular-space-occupancy MRI, and this technique has been applied to the studies of brain glioma, Schizophrenia, and Alzheimer's disease. However, validation of this technique with a gold standard method has not been reported. In this study, we compared vascular-space-occupancy MRI with a radiotracer-based positron emission tomography technique in a group of healthy subjects. It was found that regional CBV measured with vascular-space-occupancy MRI was highly correlated with that of the positron emission tomography data (R=0.79±0.10, N=8). Furthermore, absolute CBV values quantified by vascular-space-occupancy were also in excellent agreement with those by positron emission tomography (slope=1.00±0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Volume Sanguíneo
/
Determinação do Volume Sanguíneo
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Encéfalo
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Imageamento por Ressonância Magnética
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Circulação Cerebrovascular
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Tomografia por Emissão de Pósitrons
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article