Healing of late endoscopic changes in the rectum between 12 and 65 months after external beam radiotherapy.
Strahlenther Onkol
; 187(3): 202-5, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21347635
ABSTRACT
PURPOSE:
To evaluate the time course of late rectal mucosal changes after prostate cancer radiotherapy (RT). PATIENTS ANDMETHODS:
A rectosigmoidoscopy was performed at 12, 24, and 65 months after RT in 20 patients. Rectal mucosal changes (telangiectasia, congested mucosa, ulceration, stricture, and necrosis) were scored and documented according to the Vienna Rectoscopy Score (VRS, score 0-3).RESULTS:
VRS of 0 and 3, were found in 20% of patients (n = 4) and 5% of patients (n = 1), respectively at all time points. A shift of the VRS from 2 to 1 was found with incidence rates of 60% at 12 months and 20% at 65 months, which is equivalent to an improvement rate of 67%. Laser coagulation was required in 3 patients (15%) with rectal bleeding due to telangiectasia grade ≥2.CONCLUSION:
Late rectal mucosal changes are frequent after pelvic RT. Generally only the incidence rates corresponding to the initial diagnosis of the complications, independent of subsequent recovery, are reported. The results reported in the present study show that complications often improve over time. Hence, the usual reports of complication rates overestimate the proportion of patients presenting with side effects of certain grades.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proctite
/
Neoplasias da Próstata
/
Lesões por Radiação
/
Reto
/
Cicatrização
/
Sigmoidoscopia
/
Radioterapia Conformacional
/
Mucosa Intestinal
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article