Concordance between clinical and histopathologic diagnosis in recipient corneas.

ABSTRACT

PURPOSE: To specify a concordance rate between the preoperative clinical and the postoperative histopathologic diagnosis in recipient corneas referred to the pathology department of Central Eye Bank of Iran. METHODS: Concordance and discrepancy between the preoperative clinical and postoperative histopathologic diagnosis of recipient corneal buttons were evaluated. RESULTS: Overall, 340 corneal specimens were evaluated. The total concordance rate between the clinical and histopathologic diagnoses was 97.5%. The concordance rate in keratoconus, nonspecific scar and opacity, mustard gas keratopathy, combined keratoconus and dystrophy, postkeratorefractive keratectasia, and chemical burns was 100%. Discordant cases were observed in acquired corneal endothelial decompensation, corneal dystrophies, infectious keratitis, and miscellaneous causes, with the rate of 6.0%, 4.1%, 2.8%, and 16.6%, respectively. CONCLUSIONS: Our series demonstrated a significantly high concordance between the preoperative clinical and the postoperative histopathologic diagnosis in recipient corneas with different types of corneal disorders.