Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
PLoS One
; 6(2): e17010, 2011 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-21364922
ABSTRACT
DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability. However, even though Rcan1 knockout mice have pronounced spatial learning and memory deficits, the possible deleterious effects of its overexpression in DS are not well understood. We have generated a transgenic mouse model overexpressing DSCR1/RCAN1 in the brain and analyzed the effect of RCAN1 overexpression on cognitive function. TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task. However, no significant differences were observed in the performance of the memory phase of the test (removal session) nor in a step-down passive avoidance task, thus suggesting that once learning has been established, the animals are able to consolidate the information in the longer term.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proteínas Musculares
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article