Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene.
Pediatr Blood Cancer
; 56(5): 846-9, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21370421
ABSTRACT
Acute megakaryoblastic leukemia (AMKL) with t(1;22)(p13;q13) is a subset of acute myeloid leukemia (AML) representing <1% of all cases and about 70% of pediatric AMKL in the first year of life. We present a case of a 7-month-old female in whom the bone marrow karyotype showed the derivative chromosome der(22)t(1;22)(p13;q13). The RBM15-MKL1 fusion transcript was detected by RT-PCR and confirmed by sequencing analyses. FISH analyses revealed the presence of the four-way translocation t(1;22;17;18)(p13;q13;q22;q12).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Cromossomos Humanos Par 1
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Cromossomos Humanos Par 22
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Leucemia Megacarioblástica Aguda
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Proteínas de Fusão Oncogênica
Limite:
Female
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Humans
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Infant
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article