[Procedure and initial results of presymptomatic DNA studies in Huntington's chorea]. / Procedure en eerste resultaten van presymptomatisch DNA-onderzoek bij de chorea van Huntington.
Ned Tijdschr Geneeskd
; 134(14): 704-7, 1990 Apr 07.
Article
em Nl
| MEDLINE
| ID: mdl-2139182
ABSTRACT
The availability of DNA-markers more tightly linked to the Huntington's disease locus made presymptomatic and exclusion testing possible with an accuracy of up to 98%. The testing programme started in Leiden in August 1987. In 56 adults with 25% and 50% risks presymptomatic tests were performed. In 8 persons the risk was increased to 98%, in 17 it was decreased to less than 5%. In two instances the test was not informative. The remaining 29 persons have not yet been tested for different reasons. So far 3 exclusion tests were requested one showed a decreased risk, one has not yet been performed and one request was rejected. The results and the reactions to the test are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Doença de Huntington
/
Triagem de Portadores Genéticos
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Nl
Ano de publicação:
1990
Tipo de documento:
Article