[A progressive gastric cancer in which preoperative oral chemotherapy resulted in a histopathological "Grade 2" rating].

ABSTRACT

This paper describes a case of a Borrmann type 3 gastric cancer, in which the preoperative intermittent oral administration of 5'-DFUR over a short term resulted in a histopathological rating of Grade 2. A 56-year-old man preoperatively received an intermittent, oral administration of 5'-DFUR, 2, 100 mg/day. An upper gastrointestinal series and endoscopy revealed macroscopically an extremely slight remission. Histopathologically, however, a widespread, remarkable degeneration of cancer cells and fibrinogenesis of the framework were observed, these results leading to a change of rating to Grade 2.