Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human Glu1-, Lys77-, Val442-, and Val561-plasmin: a comparative study.
Biochim Biophys Acta
; 1040(1): 134-6, 1990 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-2143086
ABSTRACT
Thermodynamic and kinetic parameters for the binding of the bovine basic pancreatic trypsin inhibitor (BPTI, Kunitz inhibitor) to human Glu1-, Lys77-, Val442- and Val561-plasmin (EC 3.4.21.7) have been determined between pH 3.0 and 9.5, and from 5.0 to 45.0 degrees C. The inhibitor-binding properties to human Glu1-, Lys77-, Val442- and Val561-plasmin suggest a possible role of BPTI in modulating plasmin activity when the inhibitor is used therapeutically.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Valina
/
Inibidor da Tripsina de Soja de Kunitz
/
Inibidores da Tripsina
/
Fibrinolisina
/
Glutamina
/
Lisina
Limite:
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article