Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study.
Stroke
; 42(5): 1461-3, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21441157
ABSTRACT
BACKGROUND AND PURPOSE:
We sought to compare the distribution of the serotonin transporter gene SLC6A4 polymorphism between depressed and nondepressed poststroke patients.METHODS:
Patients with cerebral stroke admitted to hospital during a 1-year period were enrolled in a 11 case-control study. All cases and controls were genotyped for polymorphism of the serotonin transporter-linked promoter region and the single-nucleotide polymorphism rs25531.RESULTS:
Among 367 patients with cerebral stroke, 57 (15.5%) were diagnosed with poststroke depression at 1 month after stroke. In the patients with poststroke depression, 7 genotypes of the serotonin transporter gene SLC6A4 were detected, and the frequency of S/S homozygotes was significantly higher (P=0.049) than that in controls.CONCLUSIONS:
S/S homozygosity may be positively associated with the occurrence of poststroke depression in Chinese patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Polimorfismo de Nucleotídeo Único
/
Depressão
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article