[Study of efficacy of anaferon pediatric in mice infected by pandemic influenza virus A(H1N1/09)v].
Zh Mikrobiol Epidemiol Immunobiol
; (1): 83-6, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21446173
ABSTRACT
AIM:
To study efficacy of anaferon pediatric in mice infected by pandemic influenza virus A(H1N1/09)v. MATERIALS ANDMETHODS:
Influenza virus strain A/California/07/2009 (H1N1)v was used. Three groups of BALB/c mice intranasally inoculated with influenza virus were studied. First group received solution of Anaferon pediatric during 5 days before and 8 days after inoculation, 2nd group received Tamiflu during 5 days after inoculation. Distilled water was administered orally to mice from control group.RESULTS:
It was shown that Anaferon pediatric used as preventive and treatment agent in mice intranasally inoculated with 100% infectious dose of influenza virus strain A/ California/07/2009 (H1N1)v had antiviral effect, which expressed in 10-fold decreased reproduction of influenza virus in lungs of infected mice compared to control group measured 4, 6, and 8 days after inoculation.CONCLUSION:
Use of anaferon pediatric before and after inoculation with influenza virus A(H1N1/09)v was not less effective than use of Tamiflu after inoculation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Infecções por Orthomyxoviridae
/
Vírus da Influenza A Subtipo H1N1
/
Oseltamivir
/
Anticorpos
Limite:
Animals
/
Female
/
Humans
Idioma:
Ru
Ano de publicação:
2011
Tipo de documento:
Article