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Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates.
Stuchinskaya, Tanya; Moreno, Miguel; Cook, Michael J; Edwards, Dylan R; Russell, David A.
Afiliação
  • Stuchinskaya T; School of Chemistry, University of East Anglia, Norwich, Norfolk, UK.
Photochem Photobiol Sci ; 10(5): 822-31, 2011 May.
Article em En | MEDLINE | ID: mdl-21455532
A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticles via a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Neoplasias da Mama / Fármacos Fotossensibilizantes / Nanopartículas Metálicas / Ouro / Indóis / Anticorpos Monoclonais Limite: Female / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Neoplasias da Mama / Fármacos Fotossensibilizantes / Nanopartículas Metálicas / Ouro / Indóis / Anticorpos Monoclonais Limite: Female / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article