Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance.
Sci Signal
; 4(167): ra21, 2011 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-21467299
ABSTRACT
Natural killer (NK) cell tolerance to self is partly ensured by major histocompatibility complex (MHC) class I-specific inhibitory receptors on NK cells, which dampen their reactivity when engaged. However, NK cells that do not detect self MHC class I are not autoreactive. We used dynamic fluorescence correlation spectroscopy to show that MHC class I-independent NK cell tolerance in mice was associated with the presence of hyporesponsive NK cells in which both activating and inhibitory receptors were confined in an actin meshwork at the plasma membrane. In contrast, the recognition of self MHC class I by inhibitory receptors "educated" NK cells to become fully reactive, and activating NK cell receptors became dynamically compartmentalized in membrane nanodomains. We propose that the confinement of activating receptors at the plasma membrane is pivotal to ensuring the self-tolerance of NK cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Transdução de Sinais
/
Membrana Celular
/
Tolerância a Antígenos Próprios
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article